Analysis of XX SRY-Negative Sex Reversal Dogs
نویسندگان
چکیده
منابع مشابه
Sry-negative XX sex reversal in purebred dogs.
The gene responsible for testis induction in normal male mammals is the Y-linked Sry. However, there is increasing evidence that other genes may have testis-determining properties. In XX sex reversal (XXSR), testis tissue develops in the absence of the Y chromosome. Previous polymerase chain reaction (PCR) assays indicated that autosomal recessive XXSR in the American cocker spaniel is Sry-nega...
متن کاملSry-negative XX sex reversal in a French Bulldog.
Here, we describe a 3-month-old XX male French Bulldog. The diagnosis was based on the clinical signs, gonadal histology and cytogenetic analysis. Additionally, the dog was confirmed to be Sry negative by semi-quantitative reverse transcription polymerase chain reaction (sqRT-PCR). Canine Sry-negative XX sex reversal is a disorder of gonadal development where individuals who have a female karyo...
متن کاملLack of the SOX9 gene polymorphism in sex reversal dogs (78,XX; SRY negative).
The molecular background of the most frequent intersexuality syndrome in dogs (female-to-male sex reversal with the female karyotype and a lack of the SRY gene) is unknown. In this article, new cases of this syndrome are described in two unrelated American Staffordshire terrier dogs and one miniature pinscher dog subjected to cytogenetic and molecular analysis due to the presence of an enlarged...
متن کاملSox9 Duplications Are a Relevant Cause of Sry-Negative XX Sex Reversal Dogs
Sexual development in mammals is based on a complicated and delicate network of genes and hormones that have to collaborate in a precise manner. The dark side of this pathway is represented by pathological conditions, wherein sexual development does not occur properly either in the XX and the XY background. Among them a conundrum is represented by the XX individuals with at least a partial test...
متن کاملExclusion of candidate genes for canine SRY-negative XX sex reversal.
In mammals, the Y-linked SRY gene is normally responsible for testis induction, yet testis development can occur in the absence of Y-linked genes, including SRY. The canine model of SRY-negative XX sex reversal could lead to the discovery of novel genes in the mammalian sex determination pathway. The autosomal genes causing testis induction in this disorder in dogs, humans, pigs, and horses are...
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ژورنال
عنوان ژورنال: Animals
سال: 2020
ISSN: 2076-2615
DOI: 10.3390/ani10091667